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Article

In vivo bone metastases, osteoclastogenic ability, and phenotypic characterization of human breast cancer cells.

Bone - 1 Apr 2004

Rucci Nadia, Ricevuto Enrico, Ficorella Corrado, Longo Maurizio, Perez Marie, Di Giacinto Claudia, Funari Alessia, Teti Anna, Migliaccio Silvia

Abstract excerpt

Mouse bone marrow cells cultured with human breast cancer MCF-7 cell-conditioned media showed osteoclastogenesis with an increment of bone resorption, although conditioned media from an adriamycin-selected MCF-7 clone (MCF-7ADR) had no effect. Consistently, MCF-7 cells induced 5-fold more in vivo experimental osteolytic bone metastases, with no soft tissue lesions, compared to MCF-7ADR cells. Paracrine factors...

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PMID: 15050901
DOI: 10.1016/j.bone.2003.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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