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Article

p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail.

Cancer research - 1 Sept 1994

Strickler J G, Zheng J, Shu Q, Burgart L J, Alberts S R, Shibata D

Abstract excerpt

Genetic instability may underlie the etiology of multistep gastric carcinogenesis. The altered microsatellites observed in tumors with the ubiquitous somatic mutation (USM) phenotype may represent the expression of such instability. Similarly, p53 mutations may allow the accumulation of genetic alterations caused by multiple mechanisms. In 40 sporadic gastric adenocarcinomas, nine tumors (22.5%) with p53...

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PMID: 8062274

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