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Article

Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase.

Protein engineering - 1 Aug 1999

Ho Y S, Sheffield P J, Masuyama J, Arai H, Li J, Aoki J, Inoue K, Derewenda U, Derewenda Z S

Abstract excerpt

Platelet-activating factor acetylhydrolases (PAF-AHs) are unique PLA2s which hydrolyze the sn-2 ester linkage in PAF-like phospholipids with a marked preference for very short acyl chains, typically acetyl. The recent solution of the crystal structure of the alpha(1) catalytic subunit of isoform Ib of bovine brain intracellular PAF-AH at 1.7 A resolution paved the way for a detailed examination of the molecular...

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Identifiers

PMID: 10469831
DOI: 10.1093/protein/12.8.693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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