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Article

Role of tryptophan residues in interfacial binding of phosphatidylinositol-specific phospholipase C.

The Journal of biological chemistry - 31 May 2002

Feng Jianwen, Wehbi Hania, Roberts Mary F

Abstract excerpt

The phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus thuringiensis exhibits several types of interfacial activation. In the crystal structure of the closely related Bacillus cereus PI-PLC, the rim of the active site is flanked by a short helix B and a loop that show an unusual clustering of hydrophobic amino acids. Two of the seven tryptophans in PI-PLC are among the exposed residues. To test...

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Source

Identifiers

PMID: 11912206
DOI: 10.1074/jbc.M200938200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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