Article
Gene-gene synergistic effect on atopic asthma: tumour necrosis factor-alpha-308 and lymphotoxin-alpha-NcoI in Taiwan's children.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2004
Wang T-N, Chen W-Y, Wang T-H, Chen C-J, Huang L-Y, Ko Y-C
Abstract excerpt
BACKGROUND: Asthma is now known to be an inflammatory response caused by the release of inflammatory mediators and cytokines. Tumour necrosis factor (TNF) is a potent cytokine in the inflammation response of the airway, and the polymorphisms of TNF genes have been associated with asthma. OBJECTIVE: This study investigated two variants, TNF-alpha-308*2 and lymphotoxin (LT)-alpha-NcoI*1, which may predispose...
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