Article
Chimerism in humans after intragenic recombination at the haptoglobin locus during early embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 1999
Asakawa J, Kodaira M, Nakamura N, Satoh C, Fujita M
Abstract excerpt
The human haptoglobin (HP) HP*2 allele contains a 1.7-kilobase (kb) intragenic duplication that arose after a unique nonhomologous recombination between the prototype HP*1 alleles. During a genetic screening of 13,000 children of survivors exposed to atomic-bomb radiation and 10,000 children of unexposed persons, two children suspected of carrying de novo mutations at the haptoglobin locus were identified (one in...
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