Article
PGD on a recombinant allele: crossover between the TSC2 gene and 'linked' markers impairs accurate diagnosis.
Prenatal diagnosis - 1 Oct 2008
Altarescu Gheona, Eldar Geva Talia, Brooks Barry, Margalioth Ehud, Levy-Lahad Ephrat, Renbaum Paul
Abstract excerpt
OBJECTIVE: Accounting for possible recombinations in developing an accurate preimplantation genetic diagnosis (PGD) protocol based on familial haplotypes. METHODS: Haplotypes were constructed from genomic DNA in a family where the male was affected with tuberous sclerosis complex (TSC). Embryos were biopsied at day 3, and single blastomeres were analyzed by multiplex polymerase chain reactions (PCRs) including...
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