Life and death by p53.

doi:10.1002/bies.950171105

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Article

Life and death by p53.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Nov 1995

Elledge R M, Lee W H

Abstract excerpt

p53 is a multifunctional protein which plays a role in modulating gene transcription, policing cell cycle checkpoints, activating apoptosis, controlling DNA replication and repair, maintaining genomic stability and responding to genetic insults. Mutation of the p53 gene confers the single greates...

Topics

Animals
Genes, p53
Genetic Therapy
Humans
Mutation
Neoplasms

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