Article
A possible photosensitizer: Tobacco-specific nitrosamine, 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), induced mutations, DNA strand breaks and oxidative and methylative damage with UVA.
Mutation research - 15 Aug 2007
Arimoto-Kobayashi Sakae, Sakata Hiroko, Mitsu Kanayo, Tanoue Hiroyuki
Abstract excerpt
We discovered the directly acting mutagenicity of the tobacco-specific nitrosamine, 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), with UVA light (320-400nm) in Ames bacteria and phage M13mp2 in the absence of metabolic activation. We have investigated the spectrum of mutations caused by UVA-activated NNK. The majority (57%) of induced sequence changes were comprised of GC to CG, GC to TA and GC to AT....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.