Article
Spectrum of mutations in single-stranded DNA phage M13mp2 exposed to sunlight: predominance of G-to-C transversion.
Carcinogenesis - 1 Sept 1992
Negishi K, Hao W
Abstract excerpt
Sunlight is regarded to be a cause of skin cancer, though the mechanisms underlying the causation are still unclear. The genotoxic effects of sunlight are believed to be induced by pyrimidine photoproducts produced by the action of the UV portion of sunlight. However, it is not clear whether these pyrimidine modifications are the sole sources for the mutations. In the present study, we have analyzed the mutagenic...
Topics
- Bacteriophages
- Base Sequence
- Cytidine
- DNA, Single-Stranded
- DNA, Viral
- Escherichia coli
- Guanine
- Molecular Sequence Data
- Mutation
- SOS Response, Genetics
- Sunlight