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Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender.

Neuroendocrinology - 1 Aug 1999

Craft S, Asthana S, Schellenberg G, Cherrier M, Baker L D, Newcomer J, Plymate S, Latendresse S, Petrova A, Raskind M, Peskind E, Lofgreen C, Grimwood K

Abstract excerpt

Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (APOE)-epsilon4 allele. We examined the relationship of APOE and gender to peripheral insulin action and hyperinsulinemic memory facilitation in patients with AD using a sensitive measure of...

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Source

Identifiers

PMID: 10461029
DOI: 10.1159/000054469

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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