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Article

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

Journal of Alzheimer's disease : JAD - 1 Apr 2008

Reger Mark A, Watson G Stennis, Green Pattie S, Baker Laura D, Cholerton Brenna, Fishel Mark A, Plymate Stephen R, Cherrier Monique M, Schellenberg Gerard D, Frey William H, Craft Suzanne

Abstract excerpt

Intranasal insulin administration raises central nervous system (CNS) insulin levels in humans and acutely facilitates verbal memory in patients with Alzheimer's disease (AD), an effect that may differ by APOE genotype. The purpose of this study was to examine the cognitive dose response curves for intranasal insulin administration, and determine whether the effects of insulin differ between participants with...

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Source

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Identifiers

PMID: 18430999
DOI: 10.3233/jad-2008-13309
PMCID: PMC2804944

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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