Article
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.
Neurobiology of aging - 1 Mar 2006
Reger M A, Watson G S, Frey W H, Baker L D, Cholerton B, Keeling M L, Belongia D A, Fishel M A, Plymate S R, Schellenberg G D, Cherrier M M, Craft S
Abstract excerpt
Raising insulin acutely in the periphery and in brain improves verbal memory. Intranasal insulin administration, which raises insulin acutely in the CNS without raising plasma insulin levels, provides an opportunity to determine whether these effects are mediated by central insulin or peripheral processes. Based on prior research with intravenous insulin, we predicted that the treatment response would differ...
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