Article
Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.
Annals of the New York Academy of Sciences - 1 Apr 2000
Craft S, Asthana S, Schellenberg G, Baker L, Cherrier M, Boyt A A, Martins R N, Raskind M, Peskind E, Plymate S
Abstract excerpt
Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. Insulin has also been implicated in processing of beta-amyloid and amyloid precursor protein (APP). We examined the effects of intravenous insulin administration while...
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