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Article

Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice.

Scientific reports - 20 Sept 2021

Rhea Elizabeth M, Hansen Kim, Pemberton Sarah, Torres Eileen Ruth S, Holden Sarah, Raber Jacob, Banks William A

Abstract excerpt

Age, apolipoprotein E (apoE) isoform, sex, and diet can independently affect the risk for the development of Alzheimer's disease (AD). Additionally, synergy between some of these risk factors have been observed. However, the relation between the latter three risk factors has not been investigated. Central nervous system (CNS) insulin resistance is commonly involved in each of these risk factors. CNS insulin is...

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Identifiers

PMID: 34545146
DOI: 10.1038/s41598-021-98061-1
PMCID: PMC8452709

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