Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

FEBS letters - 6 Aug 1999

de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart J J, Ferrer J C

Abstract excerpt

Glucokinase (GK), a key enzyme in the glucose homeostatic responses of the liver, changes its intracellular localisation depending on the metabolic status of the cell. Rat liver GK and Xenopus laevis GK, fused to the green fluorescent protein (GFP), concentrated in the nucleus of cultured rat hepatocytes at low glucose and translocated to the cytoplasm at high glucose. Three mutant forms of Xenopus GK with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Cytosol
Share to Glucokinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose

Share to Luminescent Proteins

Share to Subcellular Fractions

Share to Xenopus

Share to Xenopus Proteins

Source

Identifiers

PMID: 10456334
DOI: 10.1016/s0014-5793(99)00971-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.PMID 10456334Read ↗

Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinaseSemantic proximity Read ↗

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.Semantic proximity Read ↗

Cell-specific roles of glucokinase in glucose homeostasis.Semantic proximity Read ↗

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.Semantic proximity Read ↗

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variantSemantic proximity Read ↗

Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase.Semantic proximity Read ↗

Localization of glucokinase gene expression in the rat brain.Semantic proximity Read ↗

Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localizationSemantic proximity Read ↗

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.Semantic proximity Read ↗

Biochemical Basis of Glucokinase Activation and the Regulation by Glucokinase Regulatory Protein in Naturally Occurring MutationsSemantic proximity Read ↗

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.Semantic proximity Read ↗

Amino acid conservation in animal glucokinases. Identification of residues implicated in the interaction with the regulatory protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.