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Article

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.

Diabetologia - 1 Jan 2012

Rees M G, Wincovitch S, Schultz J, Waterstradt R, Beer N L, Baltrusch S, Collins F S, Gloyn A L

Abstract excerpt

AIMS/HYPOTHESIS: Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) inhibition. As GCK inhibition is associated with nuclear sequestration, we aimed to determine...

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Source

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Identifiers

PMID: 22038520
DOI: 10.1007/s00125-011-2348-5
PMCID: PMC3276843

Genes

GCK
GCKR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.PMID 22038520Read ↗

Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinaseSemantic proximity Read ↗

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.Semantic proximity Read ↗

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326Semantic proximity Read ↗

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variantSemantic proximity Read ↗

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Semantic proximity Read ↗

Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.Semantic proximity Read ↗

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study.Semantic proximity Read ↗

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.Semantic proximity Read ↗

Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.Semantic proximity Read ↗

Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.Semantic proximity Read ↗

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.Semantic proximity Read ↗

Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.Semantic proximity Read ↗

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