Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

The Journal of biological chemistry - 4 May 2007

Pino Maria F, Kim Kyoung-Ah, Shelton Kathy D, Lindner Jill, Odili Stella, Li Changhong, Collins Heather W, Shiota Masakazu, Matschinsky Franz M, Magnuson Mark A

Abstract excerpt

To better understand how glucokinase (GK) missense mutations associated with human glycemic diseases perturb glucose homeostasis, we generated and characterized mice with either an activating (A456V) or inactivating (K414E) mutation in the gk gene. Animals with these mutations exhibited alterations in their blood glucose concentration that were inversely related to the relative activity index of GK. Moreover, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Glucokinase

Share to Hot Temperature

Share to Insulin

Share to Insulin Secretion

Share to Mice, Mutant Strains

Source

Identifiers

PMID: 17353190
DOI: 10.1074/jbc.M610094200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.PMID 17353190Read ↗

Biochemical Basis of Glucokinase Activation and the Regulation by Glucokinase Regulatory Protein in Naturally Occurring MutationsSemantic proximity Read ↗

Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinaseSemantic proximity Read ↗

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.Semantic proximity Read ↗

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.Semantic proximity Read ↗

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.Semantic proximity Read ↗

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.Semantic proximity Read ↗

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.Semantic proximity Read ↗

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variantSemantic proximity Read ↗

Characterizing glucokinase variant mechanisms using a multiplexed abundance assaySemantic proximity Read ↗

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.Semantic proximity Read ↗

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326Semantic proximity Read ↗

Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human <i>GCKR</i> variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.