Article
Histopathology of experimental invasive pulmonary aspergillosis in rats: pathological comparison of pulmonary lesions induced by specific virulent factor deficient mutants.
Microbial pathogenesis - 1 Sept 1999
Shibuya K, Takaoka M, Uchida K, Wakayama M, Yamaguchi H, Takahashi K, Paris S, Latge J P, Naoe S
Abstract excerpt
To investigate the pathology of invasive pulmonary aspergillosis (IPA) in detail, a new animal model of IPA was used to compare the histological features induced by three different strains of Aspergillus fumigatus; mutants devoided of exocellular protease and rodlet and their parental strain. To produce an experimental pulmonary lesion of IPA closely mimicking the human disease, suspension of agarose beads...
Topics
- Animals
- Aspergillosis
- Aspergillus fumigatus
- Cyclophosphamide
- Disease Models, Animal
- Endopeptidases
- Female
- Immunocompromised Host
- Immunosuppressive Agents
- Lung Diseases, Fungal