Article
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.
Infection and immunity - 1 Dec 1994
Smith J M, Tang C M, Van Noorden S, Holden D W
Abstract excerpt
To investigate the pathogenicity of Aspergillus fumigatus mutants lacking putative virulence factors, we have developed a new murine model of invasive pulmonary aspergillosis based on neutropenia, the major factor predisposing patients to this infection. Mice were treated with cyclophosphamide and inoculated by the intranasal route with 5 x 10(3) conidia, a significant reduction from inoculum levels used in...
Topics
- Allergens
- Animals
- Antigens, Plant
- Aspergillosis
- Aspergillus fumigatus
- Cyclophosphamide
- Disease Models, Animal
- Fungal Proteins
- Lung
- Lung Diseases, Fungal
- Male