Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the antigenomic trans-acting delta ribozyme: the alterations of the middle nucleotides located on the P1 stem.

Nucleic acids research - 15 Mar 1999

Ananvoranich S, Lafontaine D A, Perreault J P

Abstract excerpt

Our previous report on delta ribozyme cleavage using a trans -acting antigenomic delta ribozyme and a collection of short substrates showed that the middle nucleotides of the P1 stem, the substrate binding site, are essential for the cleavage activity. Here we have further investigated the effect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis Delta Virus
Share to Kinetics
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Catalytic

Share to RNA, Complementary

Share to RNA, Viral

Share to Substrate Specificity

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 10037808
DOI: 10.1093/nar/27.6.1473
PMCID: PMC148340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10037808-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the antigenomic trans-acting delta ribozyme: the alterations of the middle nucleotides located on the P1 stem.PMID 10037808Read ↗

Formation of the P1.1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans-acting hepatitis delta ribozyme.Semantic proximity Read ↗

A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes.Semantic proximity Read ↗

Nucleotides -1 to -4 of hepatitis delta ribozyme substrate increase the specificity of ribozyme cleavage.Semantic proximity Read ↗

Characterization of the trans Watson-Crick GU base pair located in the catalytic core of the antigenomic HDV ribozyme.Semantic proximity Read ↗

Presence of a coordinated metal ion in a trans-acting antigenomic delta ribozyme.Semantic proximity Read ↗

Antigenomic delta ribozyme variants with mutations in the catalytic core obtained by the in vitro selection method.Semantic proximity Read ↗

Mutational analysis of a ribonuclease III processing signal.Semantic proximity Read ↗

Design and properties of trans-acting HDV ribozymes with extended substrate recognition regions.Semantic proximity Read ↗

Design of hairpin ribozyme variants with improved activity for poorly processed substrates.Semantic proximity Read ↗

Detailed analysis of base preferences at the cleavage site of a trans-acting HDV ribozyme: a mutation that changes cleavage site specificity.Semantic proximity Read ↗

Characterizing the secondary structure and identifying functionally essential nucleotides of pH6DZ1, a fluorescence-signaling and RNA-cleaving deoxyribozyme.Semantic proximity Read ↗

Functional involvement of G8 in the hairpin ribozyme cleavage mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.