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Article

Enhancer competition between H19 and Igf2 does not mediate their imprinting.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 1999

Schmidt J V, Levorse J M, Tilghman S M

Abstract excerpt

The linked H19 and Igf2 genes on mouse distal chromosome 7 are subject to genomic imprinting. Competition between the promoters of the genes for transcription from shared enhancers has been proposed as an explanation for the coordinate expression and reciprocal imprinting of these two genes. To test this model, we have used Cre-loxP technology to generate in mice a conditional deletion of the H19 promoter and...

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Share to DNA Methylation
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Genomic Imprinting

Share to Insulin-Like Growth Factor II

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Share to RNA, Long Noncoding

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Source

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Identifiers

PMID: 10449763
DOI: 10.1073/pnas.96.17.9733
PMCID: PMC22279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhancer competition between H19 and Igf2 does not mediate their imprinting.PMID 10449763Read ↗

Location of enhancers is essential for the imprinting of H19 and Igf2 genes.Semantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

A transcriptional insulator at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene ClusterSemantic proximity Read ↗

Imprinting of Igf2 and H19 from a 130 kb YAC transgene.Semantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

Epigenetic regulation of the <i>Igf2/H19</i> gene clusterSemantic proximity Read ↗

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