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Article

Location of enhancers is essential for the imprinting of H19 and Igf2 genes.

Nature - 12 Feb 1998

Webber A L, Ingram R S, Levorse J M, Tilghman S M

Abstract excerpt

Genomic imprinting is the process in mammals by which gamete-specific epigenetic modifications establish the differential expression of the two alleles of a gene. The tightly linked H19 and Igf2 genes are expressed in tissues of endodermal and mesodermal origin, with H19 expressed from the maternal chromosome and Igf2 expressed from the paternal chromosome. A model has been proposed to explain the reciprocal...

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PMID: 9490417
DOI: 10.1038/35655

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Location of enhancers is essential for the imprinting of H19 and Igf2 genes.PMID 9490417Read ↗

Enhancer competition between H19 and Igf2 does not mediate their imprinting.Semantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

A transcriptional insulator at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Genomic imprinting in the rat: linkage of Igf2 and H19 genes and opposite parental allele-specific expression during embryogenesis.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer trackingSemantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactionsSemantic proximity Read ↗

A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene.Semantic proximity Read ↗

Deletion of a silencer element disruptsH19imprinting independently of a DNA methylation epigenetic switchSemantic proximity Read ↗

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