Article
The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals.
PLoS genetics - 1 Feb 2012
Ladouceur Martin, Dastani Zari, Aulchenko Yurii S, Greenwood Celia M T, Richards J Brent
Abstract excerpt
The role of rare genetic variation in the etiology of complex disease remains unclear. However, the development of next-generation sequencing technologies offers the experimental opportunity to address this question. Several novel statistical methodologies have been recently proposed to assess the contribution of rare variation to complex disease etiology. Nevertheless, no empirical estimates comparing their...
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