Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy.

Journal of virology - 1 Aug 1999

Pawlotsky J M, Germanidis G, Frainais P O, Bouvier M, Soulier A, Pellerin M, Dhumeaux D

Abstract excerpt

Sustained hepatitis C virus (HCV) RNA clearance is achieved in 8 to 12% of patients with chronic HCV infection treated with alpha interferon (IFN-alpha) at the approved dose of 3 MU three times a week for 6 months and in about 25% of those receiving this treatment for 12 months. We used single-strand conformation polymorphism analysis combined with cloning and sequencing strategies to characterize the genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine Transaminase
Share to Antiviral Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Interferon-alpha

Share to Interferon alpha-2

Share to RNA, Viral

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10400744
DOI: 10.1128/JVI.73.8.6490-6499.1999
PMCID: PMC112731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy.PMID 10400744Read ↗

Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcomeSemantic proximity Read ↗

Dynamics of hepatitis C virus quasispecies turnover during interferon-alpha treatment.Semantic proximity Read ↗

Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease.Semantic proximity Read ↗

Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-alpha preparations.Semantic proximity Read ↗

Dynamic coinfection with multiple viral subtypes in acute hepatitis C.Semantic proximity Read ↗

Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.Semantic proximity Read ↗

A possible role of hypervariable region 1 quasispecies in escape of hepatitis C virus particles from neutralization.Semantic proximity Read ↗

Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution.Semantic proximity Read ↗

The hypervariable region of the HCV genome changes sequentially during the progression of acute HCV infection to chronic hepatitis.Semantic proximity Read ↗

Genetic complexity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV): influence on the characteristics of the infection and responses to interferon alfa therapy in patients with chronic hepatitis C.Semantic proximity Read ↗

The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy.Semantic proximity Read ↗

Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.