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Article

Constrained genomic and conformational variability of the hypervariable region 1 of hepatitis C virus in chronically infected patients.

Journal of viral hepatitis - 1 May 2002

Hino Keisuke, Korenaga M, Orito E, Katoh Y, Yamaguchi Y, Ren F, Kitase A, Satoh Y, Fujiwara D, Okita K

Abstract excerpt

We analysed the genomic and conformational variability of the hypervariable region 1 (HVR1) of the hepatitis C virus (HCV) to evaluate the importance of its biological role. A total of 865 genotype 1b HVR1 subclones were collected from serially sampled sera in 11 patients with chronic hepatitis C, four of whom received interferon therapy. Consequently, 169 distinct sequences were examined for amino acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12010507
DOI: 10.1046/j.1365-2893.2002.00349.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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