Article
Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.
Oncogene - 1 Jul 1999
Brakebusch C, Wennerberg K, Krell H W, Weidle U H, Sallmyr A, Johansson S, Fässler R
Abstract excerpt
To investigate the role of beta1 integrin during tumor metastasis, we established a ras-myc transformed fibroblastoid cell line with a disrupted beta1 integrin gene on both alleles (GERM 11). Stable transfection of this cell line with an expression vector encoding beta1A integrin resulted in beta1A integrin-expressing sublines. Tumors were induced by subcutaneous injection of GERM 11 cells and 3 independent beta1...
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