Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.

The Journal of pathology - 1 Feb 2010

Germain Mitchel, De Arcangelis Adèle, Robinson Stephen D, Baker Marianne, Tavora Bernardo, D'Amico Gabriela, Silva Rita, Kostourou Vassiliki, Reynolds Louise E, Watson Alan, Jones J Louise, Georges-Labouesse Elisabeth, Hodivala-Dilke Kairbaan

Abstract excerpt

Laminins are expressed highly in blood vessel basement membranes and have been implicated in angiogenesis. alpha6beta1- and alpha6beta4-integrins are major receptors for laminins in endothelial cells, but the precise role of endothelial alpha6-integrin in tumour angiogenesis is not clear. We show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ductal, Breast
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin alpha6

Share to Neoplasm Transplantation

Share to Neoplasms, Experimental

Share to Neovascularization, Pathologic

Share to Vascular Endothelial Growth Factor A

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Identifiers

PMID: 19967723
DOI: 10.1002/path.2654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19967723-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.PMID 19967723Read ↗

Redefining the role(s) of endothelial αvβ3-integrin in angiogenesisSemantic proximity Read ↗

Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.Semantic proximity Read ↗

Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.Semantic proximity Read ↗

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.Semantic proximity Read ↗

HIF1α and HIF2α independently activate SRC to promote melanoma metastases.Semantic proximity Read ↗

Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development.Semantic proximity Read ↗

A Key Tyrosine (Y1494) in the β4 Integrin Regulates Multiple Signaling Pathways Important for Tumor Development and ProgressionSemantic proximity Read ↗

Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasionSemantic proximity Read ↗

Differential Effects of EGFL6 on Tumor versus Wound AngiogenesisSemantic proximity Read ↗

β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancerSemantic proximity Read ↗

Targeted disruption of the beta1 integrin gene in a lymphoma cell line greatly reduces metastatic capacity.Semantic proximity Read ↗

Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular RemodelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.