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Article

Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.

The Journal of pathology - 1 Feb 2010

Germain Mitchel, De Arcangelis Adèle, Robinson Stephen D, Baker Marianne, Tavora Bernardo, D'Amico Gabriela, Silva Rita, Kostourou Vassiliki, Reynolds Louise E, Watson Alan, Jones J Louise, Georges-Labouesse Elisabeth, Hodivala-Dilke Kairbaan

Abstract excerpt

Laminins are expressed highly in blood vessel basement membranes and have been implicated in angiogenesis. alpha6beta1- and alpha6beta4-integrins are major receptors for laminins in endothelial cells, but the precise role of endothelial alpha6-integrin in tumour angiogenesis is not clear. We show that blood vessels in human invasive ductal carcinoma of the breast have decreased expression of the...

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Share to Carcinoma, Ductal, Breast
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrin alpha6

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Share to Vascular Endothelial Growth Factor A

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Source

Identifiers

PMID: 19967723
DOI: 10.1002/path.2654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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