Targeted disruption of the beta1 integrin gene in a lymphoma cell line greatly reduces metastatic capacity.

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Article

Targeted disruption of the beta1 integrin gene in a lymphoma cell line greatly reduces metastatic capacity.

Cancer research - 1 Apr 1998

Stroeken P J, van Rijthoven E A, van der Valk M A, Roos E

Abstract excerpt

Integrins have been implicated in tumor metastasis. To investigate this, we generated beta1 integrin-negative double knockout (DKO) mutants of the highly metastatic ESb murine T-lymphoma cell line. The in vivo growth capacity of the mutants, which had lost alpha4beta1 and alpha6beta1 expression,...

Topics

Alleles
Animals
Cell Adhesion
Fibronectins
Genetic Therapy
Integrin alpha4beta1
Integrin beta1
Integrins
Laminin
Liver Neoplasms, Experimental
Lymphoma, T-Cell
Mice
Mice, Inbred DBA
Mice, Knockout
Phenotype
Receptors, Lymphocyte Homing
Splenic Neoplasms
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9537266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9537266-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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