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Article

Defective vasculature in fibronectin-receptor-deficient CHO cell tumors in nude mice.

International journal of cancer - 30 Sept 1993

Schreiner C L, Fisher M, Bauer J, Juliano R L

Abstract excerpt

The level of expression of the alpha 5/beta 1 integrin fibronectin receptor (FnR) strongly affects the growth rate of CHO cell tumors in nude mice. Here we report that alpha 5/beta 1 expression also influences the organization of the tumor vasculature. Tumors formed from CHO clones defective in FnR expression have a leaky vasculature that gives them a hemorrhagic appearance. Tumors from wild-type CHO cells, or...

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Identifiers

PMID: 8375928
DOI: 10.1002/ijc.2910550319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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