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Article

Suppression of polyploidy by the BRCA2 protein.

Cancer letters - 8 Nov 2007

Sagulenko Evgeny, Savelyeva Larissa, Ehemann Volker, Sagulenko Vitaliya, Hofmann Wera, Arnold Katrin, Claas Andreas, Scherneck Siegfried, Schwab Manfred

Abstract excerpt

Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization. We generated MX-1 clones, stably expressing BRCA2, and found that BRCA2 acts...

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Identifiers

PMID: 17686574
DOI: 10.1016/j.canlet.2007.07.003

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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