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Article

Human Cyclin a Is Required for Mitosis until Mid Prophase

18 Oct 1999

Abstract excerpt

We have used microinjection and time-lapse video microscopy to study the role of cyclin A in mitosis. We have injected purified, active cyclin A/cyclin-dependent kinase 2 (CDK2) into synchronized cells at specific points in the cell cycle and assayed its effect on cell division. We find that cyclin A/CDK2 will drive G2 phase cells into mitosis within 30 min of microinjection, up to 4 h before control cells enter...

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Identifiers

PMID: 10525536
DOI: 10.1083/jcb.147.2.295

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