The Kinetics of G2 and M Transitions Regulated by B Cyclins

doi:10.1371/journal.pone.0080861

Article

The Kinetics of G2 and M Transitions Regulated by B Cyclins

4 Dec 2013

Abstract excerpt

B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an optimization. To explore this idea, we generated HeLa BD™ Tet-Off cell lines with inducible cyclin B1- or B2-EGFP that were RNAi resistant. Cultures were treated...

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