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Article

Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution.

European journal of biochemistry - 1 Feb 1999

Vatzaki E H, Allen S C, Leonidas D D, Trautwein-Fritz K, Stackhouse J, Benner S A, Acharya K R

Abstract excerpt

A variant of bovine pancreatic ribonuclease A has been prepared with seven amino acid substitutions (Q55K, N62K, A64T, Y76K, S80R, E111G, N113K). These substitutions recreate in RNase A the basic surface found in bovine seminal RNase, a homologue of pancreatic RNase that diverged some 35 million years ago. Substitution of a portion of this basic surface (positions 55, 62, 64, 111 and 113) enhances the...

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Source

Identifiers

PMID: 10091597
DOI: 10.1046/j.1432-1327.1999.00142.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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