Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva.

Calcified tissue international - 1 Sept 1999

Virdi A S, Shore E M, Oreffo R O, Li M, Connor J M, Smith R, Kaplan F S, Triffitt J T

Abstract excerpt

Fibrodysplasia (myositis) ossificans progressiva (FOP) is an extremely rare inherited disorder in which progressive ossification of major striated muscles, often following injury, is associated with abnormal skeletal patterning. Altered expression of bone morphogenetic proteins may be a contributory cause. To examine this hypothesis, we compared the patterns of expression of bone morphogenetic proteins (BMPs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Cell Line
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Genetic Linkage

Share to Infant

Share to Myositis Ossificans

Source

Identifiers

PMID: 10441661
DOI: 10.1007/s002239900693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva.PMID 10441661Read ↗

Overexpression of an Osteogenic Morphogen in Fibrodysplasia Ossificans ProgressivaSemantic proximity Read ↗

Dysregulation of the BMP‐4 Signaling Pathway in Fibrodysplasia Ossificans ProgressivaSemantic proximity Read ↗

Dysregulation of the BMP-p38 MAPK Signaling Pathway in Cells From Patients With Fibrodysplasia Ossificans Progressiva (FOP)Semantic proximity Read ↗

Fibrodysplasia Ossificans Progressiva (FOP), a Disorder of Ectopic Osteogenesis, Misregulates Cell Surface Expression and Trafficking of BMPRIASemantic proximity Read ↗

Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.Semantic proximity Read ↗

Fibrodysplasia ossificans progressiva: clinical and genetic aspects.Semantic proximity Read ↗

Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31.Semantic proximity Read ↗

Exoneration of NF-kappaB dysregulation in fibrodysplasia ossificans progressiva.Semantic proximity Read ↗

PARESIS OF A BONE MORPHOGENETIC PROTEIN-ANTAGONIST RESPONSE IN A GENETIC DISORDER OF HETEROTOPIC SKELETOGENESISSemantic proximity Read ↗

A unique mutation of ALK2, G356D, found in a patient with fibrodysplasia ossificans progressiva is a moderately activated BMP type I receptor.Semantic proximity Read ↗

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.Semantic proximity Read ↗

[Genetic basis for skeletal disease. Establishment of novel treatments for fibrodysplasia ossificans progressiva (FOP)].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.