Article
Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31.
American journal of human genetics - 1 Jan 2000
Feldman G, Li M, Martin S, Urbanek M, Urtizberea J A, Fardeau M, LeMerrer M, Connor J M, Triffitt J, Smith R, Muenke M, Kaplan F S, Shore E M
Abstract excerpt
Fibrodysplasia ossificans progressiva (FOP) is a severely disabling, autosomal-dominant disorder of connective tissue and is characterized by postnatal progressive heterotopic ossification of muscle, tendon, ligament, and fascia and by congenital malformation of the great toes. To identify the chromosomal location of the FOP gene, we conducted a genomewide linkage analysis, using four affected families with a...
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