Article
Dysregulation of the BMP‐4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva
1 Apr 2006
Abstract excerpt
Identification of gene mutations in Mendelian disorders is often determined by linkage analysis and positional cloning, an approach that is difficult for fibrodysplasia ossificans progressiva (FOP) due to a low reproductive fitness that results in a small number of multigenerational families showing inheritance of the disease. Altered signaling pathways can be investigated as a complementary method to identify...
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