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Article

Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.

Current pharmaceutical design - 1 Jan 2012

de Gorter David J J, Jankipersadsing Vishant, Ten Dijke Peter

Abstract excerpt

Transforming growth factor-β family members, which include TGF-βs, activins and bone morphogenetic proteins (BMPs), play important roles in development and maintaining tissue homeostasis. The extracellular TGF-β family members signal across the plasmamembrane by activating type I and type II serine/threonine kinase receptors. Pertubation in TGF-β family receptor signaling has been implicated in certain diseases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22630080
DOI: 10.2174/138161212802430495

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