[Genetic basis for skeletal disease. Establishment of novel treatments for fibrodysplasia ossificans progressiva (FOP)].

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic bone formation in skeletal muscle tissue. In patients with FOP, heterozygous mutations have been identified in the BMP type I receptor, ALK2. This finding stimulates establishment of some animal models of FOP and development of novel treatments for FOP.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Activin Receptors, Type I
• Share to Bone Morphogenetic Protein Receptors, Type I
• Share to Bone Morphogenetic Proteins
• Share to Drug Design