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Article

Overexpression of an Osteogenic Morphogen in Fibrodysplasia Ossificans Progressiva

22 Aug 1996

Abstract excerpt

BACKGROUND: Fibrodysplasia ossificans progressiva is a heritable disorder of connective tissue characterized by congenital malformation of the great toes and postnatal formation of ectopic bone. Although the disorder was first described more than 300 years ago, the genetic defect and pathophysiology remain unknown. Bone morphogenetic proteins are potent bone-inducing morphogens that participate in the...

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PMID: 8678932
DOI: 10.1056/nejm199608223350804

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