Genotypic evolution in a quinolone-resistant Neisseria gonorrhoeae isolate from a patient with clinical failure of levofloxacin treatment.

doi:10.1159/000030344

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Article

Genotypic evolution in a quinolone-resistant Neisseria gonorrhoeae isolate from a patient with clinical failure of levofloxacin treatment.

Urologia internationalis - 1 Jan 1999

Tanaka M, Sagiyama K, Haraoka M, Saika T, Kobayashi I, Naito S

Abstract excerpt

Recently, a reduction in the antimicrobial susceptibility of clinical isolates of Neisseria gonorrhoeae to newer fluoroquinolones including levofloxacin in vitro has been recognized in Japan. We examined the quinolone resistance mechanisms in N. gonorrhoeae isolates from a patient with clinical failure of levofloxacin treatment. Man with gonococcal urethritis was treated with oral 100 mg levofloxacin 3 times...

Topics

Adult
Anti-Infective Agents
Chromosomes, Bacterial
DNA, Bacterial
Drug Resistance, Microbial
Genotype
Gonorrhea
Humans
Levofloxacin
Male
Neisseria gonorrhoeae
Ofloxacin
Polymerase Chain Reaction
Quinolones
Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 10436438
DOI: 10.1159/000030344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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