Article
Genomic imprinting and parent-of-origin effects on complex traits.
Nature reviews. Genetics - 1 Sept 2013
Lawson Heather A, Cheverud James M, Wolf Jason B
Abstract excerpt
Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that...
Topics
- Alleles
- Epistasis, Genetic
- Genomic Imprinting
- Humans
- Models, Genetic
- Multifactorial Inheritance
- Phenotype
- Quantitative Trait Loci
- Quantitative Trait, Heritable