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Article

Stability, activity and flexibility in alpha-lactalbumin.

Protein engineering - 1 Jul 1999

Greene L H, Grobler J A, Malinovskii V A, Tian J, Acharya K R, Brew K

Abstract excerpt

alpha-Lactalbumins and the type-c lysozymes are homologues with similar folds that differ in function and stability. To determine if the lower stability of alpha-lactalbumin results from specific substitutions required for its adaptation to a new function, the effects of lysozyme-based and other substitutions on thermal stability were determined. Unblocking the upper cleft in alpha-lactalbumin by replacing Tyr103...

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Source

Identifiers

PMID: 10436084
DOI: 10.1093/protein/12.7.581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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