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Article

Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.

Oncogene - 8 Jul 1999

Legoix P, Bluteau O, Bayer J, Perret C, Balabaud C, Belghiti J, Franco D, Thomas G, Laurent-Puig P, Zucman-Rossi J

Abstract excerpt

To determine the frequency of Wnt/Wingless beta catenin pathway alteration in human hepatocellular carcinoma, a beta catenin and APC gene mutation screening was performed in a series of 119 tumors. An activating beta catenin mutation in exon 3 was found in 18% of the cases. Among tumors lacking beta catenin mutation, no APC mutation has been evidenced in a subset of 30 cases tested. The correlation between beta...

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PMID: 10435629
DOI: 10.1038/sj.onc.1202800

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.PMID 10435629Read ↗

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Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.Semantic proximity Read ↗

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Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma.Semantic proximity Read ↗

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