Article
Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jul 1999
Joost O, Taylor C A, Thomas C A, Cupples L A, Saint-Hilaire M H, Feldman R G, Baldwin C T, Myers R H
Abstract excerpt
The reduction or loss of cytochrome P450 enzyme activity as a result of mutations in the CYP2D6 gene has been suggested as a risk factor for Parkinson's disease (PD). Conflicting results among reported studies of the prevalence of mutations among patients with PD suggested a more comprehensive genotyping and an analysis of the interactions with other suspected risk factors and family history. We determined the...
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