Article
Rectal cancer in a 13-year-old boy without a detectable germline mutation in FAP and HNPCC genes.
Journal of gastroenterology - 1 Jun 1999
Kashiwagi H, Senba S, Konishi F, Konishi M, Miyaki M, Shoji M, Kanazawa K
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC) is characterized by familial clustering and early onset. It is unclear, however, whether the early onset of colorectal cancer necessarily represents HNPCC. A 13-year-old patient had rectal cancer and underwent curative surgery. DNA from this patient was examined for replication errors (RER) and genes related to familial colorectal cancer (APC, hMSH2, and hMLH1)....
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