Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.

The Biochemical journal - 15 Aug 1999

Stone S J, Vance J E

Abstract excerpt

Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn). We previously expressed murine PSS1 in McArdle hepatoma cells. The activity of PSS1 in vitro and the synthesis of PtdSer and PtdSer-derived PtdEtn were increased, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetinae
Share to Ethanolamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Phosphatidylethanolamines

Share to Phosphatidylserines

Share to Phospholipids

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 10432300
PMCID: PMC1220436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2.PMID 10432300Read ↗

Cloning and Expression of Mouse Liver Phosphatidylserine Synthase-1 cDNASemantic proximity Read ↗

Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice.Semantic proximity Read ↗

Cloning of a Chinese hamster ovary (CHO) cDNA encoding phosphatidylserine synthase (PSS) II, overexpression of which suppresses the phosphatidylserine biosynthetic defect of a PSS I-lacking mutant of CHO-K1 cells.Semantic proximity Read ↗

Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.Semantic proximity Read ↗

Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells.Semantic proximity Read ↗

Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.Semantic proximity Read ↗

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase.Semantic proximity Read ↗

Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids.Semantic proximity Read ↗

Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase.Semantic proximity Read ↗

[Genetical and biochemical studies on the metabolisms and biological roles of membrane phospholipids in mammalian cells].Semantic proximity Read ↗

Phosphatidylethanolamine <i>N</i> ‐methyltransferase <i>(PEMT)</i> gene expression is induced by estrogen in human and mouse primary hepatocytesSemantic proximity Read ↗

Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.