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Article

Perinatal Nicotine Exposure-Induced Cardiac Phenotype Is Mediated by miR-1-MIAT Interaction and Is Transmitted Transgenerationally.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Mar 2026

Chuang Tsai-Der, Yu Celia, Liu Jie, Khorram Omid, Umar Soban, Rehan Virender K

Abstract excerpt

Cardiac fibrosis in perinatally nicotine-exposed hearts has been demonstrated, but the underlying mechanisms remain unclear. Moreover, whether this phenotype is transmitted transgenerationally, as has been shown for perinatal nicotine exposure-induced asthma, is not known. MicroRNA (miR)-1, which targets a key extracellular matrix (ECM) protein, connective tissue growth factor (CTGF), and myocardial...

Topics

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Connective Tissue Growth Factor
Heart
MicroRNAs
Myocardium
Nicotine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prenatal Exposure Delayed Effects

Rats, Sprague-Dawley

RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 41874368
DOI: 10.1096/fj.202504804R
PMCID: PMC13185961

Genes

F3
F2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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