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Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

15 Apr 2004

Abstract excerpt

High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin. To examine whether GCS is a target for cancer therapy, we have designed and tested the effects of antisense oligodeoxyribonucleotides (ODNs) to GCS on gene expression and...

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PMID: 14967819
DOI: 10.1194/jlr.m300486-jlr200

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