Article
The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.
Cancer research - 15 Mar 1991
Kaplan O, Jaroszewski J W, Clarke R, Fairchild C R, Schoenlein P, Goldenberg S, Gottesman M M, Cohen J S
Abstract excerpt
In order to identify changes in 31P nuclear magnetic resonance (NMR) spectra associated with multiple drug resistance (MDR), a number of wild type and drug-resistant cancer cell lines were studied. The resistant cells included cells selected with various drugs, mainly Adriamycin, as well as cells transfected with the human multidrug resistance gene (MDR1 gene), which encodes P-glycoprotein. In most cases, 31P NMR...
Topics
- Adenosine Triphosphate
- Cell Survival
- Deoxyglucose
- Doxorubicin
- Drug Resistance
- Humans
- Magnetic Resonance Spectroscopy
- Phenotype
- Transfection
- Tumor Cells, Cultured